A unified strategy of general utility to target furo[3,2-b]-furanone framework present in a range of diverse natural products is delineated. The method emanating from a typical Morita-Baylis-Hillman adduct has been utilized to construct linearly and angularly fused furo[3,2-b]-furanones in a bidirectional approach through series of cascades. This reaction sequence has been utilized by our group in recent past to direct our studies towards the synthesis of complex natural products like neovibsanins, rubrifloradilactone-C, Plakortones etc. to name a few.References. Mehta, G.; Bhat, B. A. Tetrahedron Lett. 2009  , 50, 2474.Mehta, G.; Bhat, B. A.; Kumara, T. H. S. Tetrahedron Lett. 2009  , 50, 6597.Mehta, G.; Bhat, B. A.; Kumara, T. H. S. Tetrahedron Lett. 2010  , 51, 4069.Lone A, Bhat, B. A.; Mehta, G. Tetrahedron Lett. 2013  , 54, 5619

Strategies towards furo[3,2-b]furanones present in bioactive natural products

248th National Meeting (2014)

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