In molecules that possess sp3-hybridized stereogenic carbon atoms, identification of chirality is trivial. However, in molecules that do not possess such atoms, the identification of the presence of chirality is not straightforward. We hypothesize that many groups of conformationally chiral molecules exist in Nature, but their chiral properties are unappreciated. We present the synthesis and study of natural products that possess chirality by virtue of their conformation.

Synthesis of natural products with conformational chirality

248th National Meeting (2014)

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