Our recently data have demonstrated that some plant viral particles (including tobacco mosaic virus, TMV) can significantly accelerate the osteogenesis of bone marrow stromal cells without supplementing any exogenous protein or drug. In addition, the surface functionalization of viral particles can further augment such cellular response. Here we report that the combination of the surface modification of TMV with controlled 3D assembly of TMV particles can serve as programmable building blocks to modulate cellular responses. Our approach took advantage of the unique structural features of TMV. It may lead to novel tissue engineering materials which can simultaneously fulfill the hierarchical structural, mechanical and biochemical requirements.

Tobacco mosaic virus as a powerful anisotropic building block to modulate cellular responses

248th National Meeting (2014)

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