The phosphodiesterases (PDE) are a family of enzymes whose function is to control the levels of the signaling molecules cyclic adenosine monophosphate (cAMP) and/or cyclic guanosine monophosphate (cGMP) within the cell. The PDEs accomplish this by hydrolysis of the cyclic monophosphate to the silent ring-opened monophosphate. The development of PDE inhibitors has resulted in multiple non-selective and several selective PDE drugs. Based on the �drugability� of inhibitors of this enzyme family and expanded biological understanding of the targets, many efforts to develop selective inhibitors have been carried out over the past two decades. The successful drugs and the lead compounds from each of the PDEs will be presented.

Phosphodiesterases: Validated targets for medicinal intervention

248th National Meeting (2014)

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