The MALDI MS study of the products of chelidonic acid, CA, and thiodiglycolic acid, TDGA, produced from reaction with Group IVB metallocene dichlorides is reported.  The products from both Lewis bases are polymeric and exhibit inhibition of a variety of cancer cell lines. In each case, ion fragments and ion fragment clusters are found that correspond to greater than one unit in length and consistent with the proposed repeat unit. As in other studies with metal-containing condensation polymers, ion fragments are formed from bond scission along the polymer backbone at the metal sites.  Further, loss of groups attached to the metal, here Cp groups, often occur at the sites of bond breakage.  The mildness of MALDI MS is evident from the lack of breakup of the chelidonic acid and thiodiglycolid acid moiety other than loss of oxygen, CO, or CO2 which is typical for acids.

Fragmentation MALDI TOF MS of polyesters formed from reaction of the salts of chelidonic acid and thiodiglycolic acid with group IVB metallocene dichlorides

248th National Meeting (2014)

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