Amphiphilic PVC-g-POEM graft copolymer was prepared by simple one step atom transfer radical polymerization (ATRP) process and characterized by fourier transform infrared spectroscopy (FT-IR) and gel permeation chromatography (GPC). The molecular weight of the copolymer increased by increasing the POEM as measured by GPC. Transmission electron microscope (TEM) and small angle X-ray scattering (SAXS) analysis revealed the microphase-separated structure of PVC-g-POEM and the domain spacing increased from 59.3 to 86.1 nm with increasing grafting degree. Contact angle measurement showed that the hydrophilicity of the membrane increased by increase in the presence of POEM in the graft copolymer. Attachment of bacteria and mouse embryonic fibroblast cells on the membrane surface was visualized by the scanning electron microscope (SEM). Protein adsorption and eukaryotic and prokaryotic cell adhesion tests showed that the bioinert properties of membranes were significantly increased with POEM content.

Synthesis of ampiphilic PVC-g-POEM copolymer and application as bioinert membrane

248th National Meeting (2014)

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