Alcoholic beverages such as beer and wine are well known to potently stimulate gastric acid secretion. This study demonstrates that gastric acid secretion on a functional and gene regulatory level is differently affected by red wine vs. white wine in healthy subjects and in parietal cells in culture. Organic acids, by acting on extracellular proton transport involved in gastric acid secretion, are the wine constituents chiefly responsible for this effect. Furthermore, we confirmed that ethanol also stimulates mechanisms of gastric acid secretion, although addition of ethanol to a biomimetic mixture of wine organic acids attenuated their pro-stimulatory effect. This study gives new insights into the understanding of how wine and its constituents influence mechanisms of gastric acid secretion.

Identification of organic acids in wine that stimulate mechanisms of gastric acid secretion in healthy subjects

248th National Meeting (2014)

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