The introduction of the requirement for TK data from toxicology studies conducted with crop protection products has introduced new challenges. Micro-sampling offers key advantages over conventional sampling techniques for supporting PK/TK studies in rodents. Ethically advantageous, it uses a less invasive sampling procedure and a reduction in the number of animals. Scientifically it offers the benefit of PK/TK data derived from serial rather than composite bleeds. Plasma micro-sampling offers advantages over other microsampling techniques such as dried blood spots as the use of plasma has long been accepted by regulators. A comparison between plasma micro-sampling and conventional sampling used during an investigative PK study performed in rodents. Test material was administered intravenously to mice and rats: blood samples were collected by both sampling regimens. The micro-sampling procedure will be presented together with a comparison of the PK data generated using this technique with data derived from conventional blood sampling.

Micro-sampling for rodent studies

248th National Meeting (2014)

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