We performed a crossover, clinical evaluation of PURENERGY� in healthy male adults (n=12). The purpose of this study was to evaluate the safety, relative bioavailability and pharmacokinetics of PURENERGY (pTeroPure pterostilbene-caffeine co-crystal) as compared to pTeroPure and caffeine alone.pTeroPure is a pure (>99%), nature-identical, all-trans pterostilbene. Pterostlibene is the dimethylated analog of resveratrol found naturally in blueberries and grapes. Like resveratrol, pterostilbene is thought to have several health beneficial properties including promoting heart health, cognitive function and healthy metabolism as well as being an anti-oxidant.  pTeroPure is the only GRAS pterostilbene ingredient and has been shown to have superior bioavailability as compared to resveratrol as it is more easily transported into the cell and more resistant to degradation and elimination. It is anticipated that this unique co-crystal ingredient can deliver the benefits of pterostilbene coupled with the energy boost of caffeine. Results from our clinical trial demonstrated that PURENERGY delivers almost 30% more caffeine into the blood than caffeine taken by itself (as measured by AUC and CMax); this difference is highly significant (AUC ratio=1.28, p<0.001 and CMax ratio=1.09, p<0.001). Further, PURENERGY puts about 50% more total pterostilbene into the blood than pTeroPure; this difference is also highly significant (CMax 1.53, p=0.004 and AUC 1.46, p=0.003). There were no adverse events observed in this study.Recently, caffeinated energy products have been coming under increased regulatory and political scrutiny regarding the possible risks of consuming high amounts of caffeine. PURENERGY offers an exciting alternative to traditional caffeine; empowering formulators of energy products to reduce the total amount of caffeine present in their products without sacrificing consumers' expectations.

Clinical evaluation of <i>PURENERGY�</i>, a novel co-crystal ingredient comprised of pterostilbene and caffeine, in healthy adults

248th National Meeting (2014)

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Clinical evaluation of PURENERGY�, a novel co-crystal ingredient comprised of pterostilbene and caffeine, in healthy adults