Energy drinks may contribute extra calories possibly causing weight gain and obesity. Ginseng extract is often used in energy drink formulations to improve cognitive performance and reduce mental fatigue. A recent study has found that in addition to ginsenosides, a new previously unknown bioactive compound, named gintonin was isolated from Panax ginseng. Gintonin is a lysophosphatidic acid (LPA) receptor ligand composing of mixture of at least 6 different glycoproteins composed of amino acids, fatty acids, and carbohydrates. Recent studies have found that it attenuated Alzheimer's disease-related neuropathies by promoting non-amyloidogenic processing. The anti-obesity effect of gintonin has been investigated in 3T3-L1 cells since LPA has been previously shown to inhibit adipogenesis. Administration of gintonin to 3T3-L1 preadipocytes inhibited adipocyte development and attenuated stimulation of pioglitazone-induced adipogenesis. Energy drinks with gintonin in energy drinks may inhibit fat accumulation as well as improve cognitive function.

Gintonin, a novel glycoprotein extracted from <i>Panax ginseng</i>, improves cognitive function and reduces fat accumulation in adipocytes

248th National Meeting (2014)

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Gintonin, a novel glycoprotein extracted from Panax ginseng, improves cognitive function and reduces fat accumulation in adipocytes