While natural products are being rediscovered as drug leads, macrocyclic natural products have been largely ignored as therapeutic leads.  Containing rings with 12 or more atoms, these macrocyclic natural products generally exceed the rule-of-five but still exhibit positive drug-like physicochemical and pharmacokinetic properties. This talk will focus on some recent examples from the CAS databases and conclude with a study of synthetic pathways for making these valuable synthetic targets in the lab.

Rediscovering macrocyclic natural products as drug leads

248th National Meeting (2014)

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