The physical principles by which molecular machines function are very different than those governing the operation of even very small mechanical machines.  Understanding these differences is leading to significant progress in the design and construction of machines that use chemical, electrical, mechanical, or light energy to carry out molecular tasks for nanotechnological applications.  The analysis here shows that the essential principle for designing nano-scale energy converters is the combination of a catalytic function with an allosteric sensing function.

Microscopic reversibility: The organizing principle for molecular machines

248th National Meeting (2014)

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