We have successfully developed a unique chiral ligand SPRIX possessing isoxazoline coordination sites on a rigid spiro backbone. SPRIX has proven to promote useful Pd catalyses due to its low s-donor ability, which cannot be achieved with other ligands bearing phosphorus and/or nitrogen coordination sites. The exceptional property of SPRIX stimulated us to further explore useful asymmetric catalysis. Herein we report novel enantioselective reactions catalyzed by the Pd-SPRIX complex, which provided optically active heterocyclic compounds.

Recent progress of enantioselective catalysis promoted by Pd-SPRIX

248th National Meeting (2014)

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