Chiral sulfoxides belong to a class of compounds widely used in asymmetric synthesis due to its availability and high asymmetric induction exerted by the chiral sulfinyl group. Chiral sulfoxides are incorporated into drugs or molecules with biological activity like: proton pump inhibitor, ACAT inhibitor and anticancer. These kinds of reactions involving chiral sulfoxides are already extremely well known, however, little is known in the literature on the use of this chemical species in coupling reactions, we describe a methodology for coupling reactions between halides vinyl sulfoxides and organotrifluoroborates salts through reactions of the Suzuki-Miyaura type catalyzed by transition metals such as Pd.

Synthesis and functionalization of vinyl sulfoxides halides

248th National Meeting (2014)

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