A copper free intramolecular azide-alkyne cycloaddition reaction of �-lactam azide has been described. The present strategy involves the incorporation of alkyne through O-alkylation of the hydroxy �-lactam with various propargylic halides. A variety of fused triazoles with an oxazepine skeleton of �-lactams.

Copper free intramolecular �-lactam tethered azide-alkyne [3+2] cycloaddition: An efficient synthesis of enantiopure tricyclic �-lactam triazoles

248th National Meeting (2014)

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