The use of Me3SiO?/Bu4N? as a general activation of organotrimethylsilanes for addition reactions has been established. The broad scope of the method offers trimethylsilanes (including acetate, allyl, propargyl, benzyl, dithiane, heteroaryl and aryl derivatives) as bench stable organometallics which can be readily utilized as carbanion equivalents for synthesis. Reactions are achieved at r.t. with no specialised precautions required that are common place for other organometallics.

Bu<sub>4</sub>N<sup>+</sup>-TMS oxide as a general fluoride-free method for the promotion of addition reactions with organotrimethylsilanes

248th National Meeting (2014)

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Bu4N+-TMS oxide as a general fluoride-free method for the promotion of addition reactions with organotrimethylsilanes

Bu₄N⁺-TMS oxide as a general fluoride-free method for the promotion of addition reactions with organotrimethylsilanes