The Daphniphyllum alkaloids are a family of plant derived natural products with promising anti-tumor activities. We have accessed the tertiary, bridgehead amine at the core of many Daphniphyllum alkaloids via an N-centered radical tandem cyclization. Our approach is anticipated to provide Daphniyunnine C and Daphnicyclidin A in less than 10 steps from known lactone.

Synthesis of Daphniphyllum alkaloid cores via N-centered radical tandem cyclization

248th National Meeting (2014)

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