Phenolic compounds exhibit interesting properties - such as antioxidant, antimicrobial activities as well as plasticizing effect � and are commonly used as additives in polymer matrices (e.g., bisphenol A) or cosmetic formulations (e.g., ferulic acid). Unfortunately these molecules are often synthesized from fossil resources and some of them may have some serious toxicity (e.g., endrocrin perturbation effect of bisphenol A).Dedicated to the valorization of biorefineries by-products, we recently developed a novel family of renewable macrobisphenols through a chemo-enzymatic process under mild conditions. Made of bio-based polyols and ferulic acid derived respectively from plant polysaccharides and lignocellulose, these renewable macrobisphenols show potent antioxidant and antimicrobial activities and exhibit a high thermal stability and plasticizing effect.This communication focuses on the synthesis and the study of a library of macrobisphenols in order to improve their biological and physico-chemical properties through the determination of structure-activity relationships.

Chemo-enzymatic synthesis and properties evaluation of new biobased macrobisphenols derived from ferulic acid

248th National Meeting (2014)

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