The chemistry of carbon monoxide releasing molecules (CORMs) is of current interest due to the identification of several beneficial health effects associated with the controlled administration of small amounts of CO. These benefits include anti-inflammatory and antiapoptotic effects as well as the promotion of vasodilation and protection of tissues against reperfusion injury. To date, the vast majority of CORMs reported are low-valent metal-carbonyl compounds, some of which exhibit photoinduced CO-release in the visible region. Metal-carbonyl compounds, however, have limitations including the fact that most cannot be controlled in terms of the location and timing of the CO-release, the CO-release may be reversible, and the production of potentially reactive low-valent metal species as photo-remnants of the CORM. Flavonols are a class of biological molecules known for their antioxidant properties. The research presented will demonstrate that flavonols can also exhibit photoinduced CO-release reactivity and that this reactivity is highly tunable through structural modifications, metal coordination, and encapsulation of the flavonol within a microenvironment.

New family of flavonols: Tunable photoinduced carbon monoxide releasing agents

248th National Meeting (2014)

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