Isothiazoles are bioactive heterocyclic compounds, isotianil was developed by Bayer and Sumitomo Chemical as novel fungicide which induces systemic acquired resistance in plants. On the basis of our former studies on plant elicitors, in order to find more chemical structurally diverse N and S containing novel heterocyclic lead compounds, several kinds of novel isothiazole derivitives with both systemic acquired resistance and insecticidal or fungicidal activity were designed and synthesized, partial target molecules designed and synthesized as shown in figure 1. Preliminary bioassay results indicated that some compounds showed high systemic acquired resistance, some compounds kept both fungicide or insecticide activity. These results provided an integrated new method for plant protection.

Synthesis and biological activity of novel isothiazole derivatives

248th National Meeting (2014)

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