For many regulated pesticides the best available toxicological data lead to an assumption that certain degradation products contribute (along with the parent) to specific effects on nontarget organisms. Modeling of formation and decline of these degradates may be problematic because of data limitations such as inadequate decline, uncertainties regarding unextracted residues, microbial population changes over time, and uncertain alternative degradation pathways. A more simplified modeling in single or multiple steps of the total toxic residues may provide sufficient exposure information to answer the risk questions posed by regulators. However, parameterization of inputs to modeling will depend on the relative toxicities and chemical properties of each of the residues of concern. The challenge is to find a way of estimating risk which is less susceptible to data inadequacies that inhibit achieving a satisfactory solution to the full kinetic modeling of all degradation pathways. Representative approaches and criteria for their use will be discussed.

Simplified approaches to exposure analysis of the total toxic residues of a pesticide in a regulatory setting

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.