Electrospun Fibrous Membrane for Reducing Postoperative Peritoneal Adhesion and for Targeted Drug Delivery Shanshan Xu1, Benjamin Chu2, Benjamin Hsiao2, and Charles C. Han1 1 State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China 2 Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA * Correspondence authors: Charles C. Han, c.c.han@iccas.ac.cn, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China. Tel.: +86 10 82618089; fax: +86 10 62521519 Shanshan Xu, xuss04@iccas.ac.cn, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China. Tel.: +86 10 82618089; fax: +86 10 62521519 Abstract Peritoneal adhesion is the most common adverse effect after abdominal surgery or inflammation. Till now, only solid barriers have been used successfully in clinical cases by acting as a physical separator during peritoneal healing. In this study, the casting film and fibrous membrane made from poly(lactic-co-glycolic acid) (PLGA) and polylactic acid-block-polyethylene glycol (PLA-b-PEG) mixtures were used and their chemical composition and performance have been studied in detail. They were observed to have almost identical adhesion-prevention performances as a commercial film consist of only PLGA, but have better flexibility and biocompatibility. Through the whole elaboration about this comprehensive and meticulous investigation from pathology, toxicity and immune response, the electrospun membrane with ECM-like (extracellular matrix) structure caused only normal acute inflammatory response and less intestinal obstruction. The feasibility, validity and safety were finally evaluated in a randomized, single-blind, placebo-controlled clinical trial. The statistical result of 150 patients confirmed that the fibrous membrane could reduce the incidence of abdominal adhesion between incision and organs directly underneath. A final approval from FDAC has been granted. Several examples of further investigations on drug carrying and targeted delivery have been performed and will be discussed. Key word: electrospun fibrous membrane, anti-adhesion, biocompatibility

Electrospun fibrous membrane for reducing postoperative peritoneal adhesion and for targeted drug delivery

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.