Targeted drug delivery utilizing nanoparticle-forming polymeric systems is at the forefront of chemistry, biology and materials science. We are investigating a range of novel functionalized triblock copolymers composed of PEG and oligopeptide modules with the goal of elucidating superior candidates for encapsulation and delivery of clinically important anticancer drugs. In this presentation, we describe the design, synthesis, and structure-function studies of a series of novel triblock polymers (MePEGNH-b-Poly-(crosslinking AA1)x-b-Poly-(core [AA2]y-co-[AA3]z)-NHAc) that incorporate d- or l-amino acid moieties in the hydrophobic core block. The impact of the crosslinking and core block moieties on physical properties (e.g. CMC, solubility, conformation), formulation, and drug delivery efficacy will be compared to more traditional diblock and triblock polymers.

Design, synthesis, and structure-function studies of novel triblock copolymers

249th National Meeting (2015)

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