The lecture will present our latest advances in the field of folding single polymer chains into defined nanoparticle structures. Initially, the so-called 'selective point folding' approach will be discussed on several examples, evidencing that single polymer chains can be folded and unfolded via independent and orthogonal interaction points not unlike naturally occuring biomacromolecules. Specifically, orthogonal additional binding principles beyond hydrogen donor/acceptor systems will be discussed in the context of single chain folding. Secondly, single chain polymer folding via so-called 'repeat unit folding' will be explored and avenues towards inherently fluorescent as well as catalytically active single chain nanoparticles will be discussed. A special focus will be placed on using photochemical approaches to collapse single chains. In addition, analytic approaches towards evidencing single chain nanoparticle formation will be shown with an emphasis on DOSY and DLS methodologies.

Folding single polymer chains

249th National Meeting (2015)

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