A regioselective transition metal-catalyzed cycloisomerization reaction of boron-containing alkynyl epoxides toward C2- and C3-borylated furans has been developed. It was found that the copper catalyst as well as the gold catalyst with more basic triflate counterion favor boryl migration toward C3-borylated furans, whereas employment of the cationic gold hexafluoroantimonate affords C2-borylated furan via a formal 1,2-hydrogen shift.

1,2-Boryl migration empowers regiodivergent synthesis of<br />
borylated furans

249th National Meeting (2015)

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1,2-Boryl migration empowers regiodivergent synthesis of<br /> borylated furans