Protein glycosylation is an important post-translational modification. It enhances the functional diversity of proteins and alters their stability, binding affinity, substrate specificity and biological activity. However, because of the complexity of glycoproteins and glycan structures, establishing connections between glycan structures and their effects is difficult. Recently, we demonstrate that chemical synthesis can be employed as a useful tool to determine the effects of protein glycosylation. The more precise understanding of protein glycosylation would aid in the development of enzymes and biotherapeutics with improved performance.

Chemical synthesis as a tool to study protein glycosylation

249th National Meeting (2015)

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