A new water soluble polyester (PIOT) with fluorescent property was synthesized and characterized, and further formed PIOT-HA NPs with anionic hyaluronic acid (HA) by electrostatic interactions in aqueous solution. Through specific interactions between HA locating on the surfaces of PIOT-HA NPs and CD44 protein expressed on the cancer cell line MDA-MB-231, PIOT-HA NPs could selectively bind to cancer cells and be use to image. Upon white light irradiation, the PIOT-HA NPs sensitized oxygen to generate reactive oxygen species (ROS). The ROS could inactivate the neighboring CD44 protein, which inhibits invasion of MDA-MB-231. In addition, the PIOT-HA NPs showed degradability towards treatments of alkali and/or hyaluronidase, which could reduce accumulating of the PIOT-HA NPs in vivo. These findings demonstrated that the PIOT-HA NPs could be developed as a multi-functional and safety material for cancer diagnosis and treatment.

Degradable nanoparticles for light-assisted cancer invasion inhibition

249th National Meeting (2015)

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