The interaction of gold(III) diammines complexes [Au(en)Cl2]Cl, [Au(en)2]Cl3, and [Au(DACH)Cl2]Cl with Glutathione have been studied spectroscopically and electrochemically in aqueous solution. The shifts in NMR resonance shows oxidation of Glutathione to Glutathione disulfide (GSSG) and resonance for free diammine ligand obtained at reaction ratio (1:2) gold(III) complex to GSH implying reduction of gold(III) to elemental gold(0). UV-VIS Kinetic scan shows formation of intermediate with formula [Au(diammine)(SG)2]+ which is not observed in NMR the Kinetics of this substitution step was also investigated using UV-VIS technique at three different temperatures, pseudo-first order rate constant and activation parameters (∆Hǂ and ∆Sǂ) for intermediate formation were determined. ComplexaK M-1. min-1∆Hǂ kJ. mol-1∆Sǂ JK-1mol-1 [Au(DACH)Cl2]Cl16.5 + 0.2937.3 + 0.75-85.5 + 2.70 [Au(en)Cl2]Cl102 + 0.7118.3 + 0.94-136 + 2.92 [Au(en) 2]Cl350.5 + 3.0010.7 + 1.64-168 + 5.21 All values expressed as (Average + SDEV) Acknowledgement This research was supported by the KFUPM Research Committee under DSR project # IN121049.

Study of glutathione interactions with anticancer Gold(III) diammines complexes using NMR, UV-VIS and electrochemistry

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.