Biological oxidation reactions are often catalyzed by metalloenzymes via high-valent iron centers generated by dioxygen activation. Key nonheme iron examples are the mononuclear oxoiron(IV) oxidants associated with TauD and related oxygenases and the FeIV2O2 diamond core found for intermediate Q of soluble methane monooxygenase. Oxoiron(V) species may also be involved in the mechanisms of some dioxygenases. Our efforts have focused on generating synthetic analogs of such reactive species; low temperatures are used to extend their lifetimes and allow their spectroscopic characterization. Appropriate ligand design is required to enhance the prospects of success in generating the target high-valent iron-oxo unit. The synthesis, structures, and reactivity of these novel intermediates will be discussed.

Amazing nonheme high-valent iron-oxo reactivity landscape

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.