Synaptotagmins (Syt) are membrane binding proteins that regulate the release of hormones and neurotransmitters through exocytosis. Previous works suggest that the C2A domains of Syt1 and Syt7, two members of the Syt protein family, have different membrane-docking mechanisms despite their structural similarity. Here, we report the MD simulations of both Syt1 and Syt7 C2A domains associated with membrane of mixed POPC and POPS (3:1) to identify the origin of the differences. We also analyze how the simulation results depend on the initial orientations of the C2A domains with respect to the membrane.

Comparisons of Synaptotagmin 1 and Synaptotagmin 7 C2A domains in membrane associations by molecular dynamic simulations

249th National Meeting (2015)

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