A novel method for the formation of monodisperse microsphere hydrogels has been developed. This technique allows for the creation of microgels tailored for individual applications with minimal variation to the formation procedure, facilitating a robust yet facile production process. Allyl functionalized polymers are crosslinked with difunctional thiol species, in the presence of the desired cargo, to form the hydrogel products in the range of 10-30 microns. This process has been implemented to create hydrophobic, hydrophilic, and amphiphilic structures which can be loaded with a range of cargo including, but not limited to, small molecule drugs and biological therapeutics. Model release data has been obtained and indicates a linear release profile sustained over an extended period. The release rate of the cargo can be tailored by either the choice of crosslinking species or doping of the system with poly(glycidol). Gels formed from crosslinked poly(glycidol)s have shown intriguing physical characteristics and will be investigated for their application in inhalants and vaccines.

Printing of polymer hydrogels in micron sizes for the Co- and sequential delivery of drugs

249th National Meeting (2015)

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