Nanotechnology is a burgeoning field that is full of opportunities for exploitation in biomedical applications. Quantum dots (QDs) are particularly interesting because of their intense fluorescence emission. In one project, we are using QDs as nano-carriers for gene delivery. The field of gene therapy has had many set-backs with the use of modified viruses. As an alternative, many researchers have turned to explore non-viral carriers. A benefit of using nanocrystals for this application is a defined structure and built-in fluorescence visualization of the cellular delivery mechanisms. In a second project, we are studying the serotonergic system in neurons. By using QDs, we can tag single serotonin receptors, and visualize their cellular signaling behaviors. In doing this, we trace their cellular trafficking through the endosomal system. By comparing this trafficking in “basal” and model “disease” states we aim to gain more information about the role of serotonin receptors in psychological disorders. Finally, a separate project aims to synthesize and functionalize MRI-active QDs for theronostic applications in neurological disorders.

Design of multifunctional quantum dot conjugates for biomedical applications

249th National Meeting (2015)

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