Cyclic peptides (CPs) and CP-polymer conjugates self-assemble into high aspect ratio cyclic peptide nanotubes (CPNs) with tunable channel diameters and interior functionality. The guided CPN growth within the cylindrical block copolymer (BCP) microdomain overcame challenges to reduce pore size in polymeric membranes and to synthesize high aspect ratio nanotubes with controlled length and vertical alignment. It opened a viable approach to generate porous membrane with vertically aligned uniform sub-nanometer channel and potential for nanotube interior modification. To this end, we have been focusing on two aspects. One is to develop systematic understanding in the kinetic pathway of co-assembly of cyclic peptide-polymer conjugate and BCP. The other is how to manipulate CPN growth. I will discuss our recent results in these two fronts and share our thoughts regarding how to generate CPNs with statistically defined sequences.<br/>

Controlled assemblies of cyclic peptide-polymer conjugates toward sub-nanometer porous membrane

249th National Meeting (2015)

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