One of the first organometallic compounds that is still used against cancer is the square planar Cisplatin, (Cl2(NH3)2Pt). In our laboratory we have synthesized a series of tin compounds with a similar dichloro feature, e.g. R2SnCl2. Normally such systems would be tetrahedral at tin, but by incorporating R groups with pendant ligand atoms such as O, S etc. we can transform them into potentially hexa-coordinated structures. Thus we have been synthesized and tested a series of simple organotin and transition metal-substituted organotin complexes, R2SnCl2, on MDA- MB231 breast cancer cells (grown in DMEM media) and MCF 10A non-tumorigenic cells (grown in DMEM-F12 media). The functionality R = CH2C6H4-o(EMe) (E = O, S, CH2); (C5H5)Fe(CO)2 were examined. Using established protocols the IC50 for 24 hours was determined and for the MDA-MB 231 cell line an IC50 of 26-nanomolar final concentration was observed, and for the MCF 10A cell line an IC50 of 15-nanomolar final concentration was observed! Against all cell lines the compounds act in an apoptotic manner, and surprisingly the compounds with the capacity to be octahedral were more active than those without such a capacity, e.g. E = CH2 . All compounds exhibit apoptotic properties. Support of this research was provided by the NIH MARC (grant #5T34GM008048) and RISE (grant #5R25GM069621-08) programs.

Cytoselectivity of organotin and transition metal-substituted organotin compounds on cancer cells

249th National Meeting (2015)

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