We present the fabrication of a series of photo-crosslinked poly(ε-caprolactone) triacrylate (PCLTA) substrates with defined gradients in stiffness and regulation of primary rat smooth muscle cells (SMCs) on them. The gradient strength was calculated to be 3.4, 13.4, 26.1 and 48.0 kPa/mm, increasing along the direction from the soft end to the stiff end of the substrates. SMC migration was directed on the substrates from the soft end to the stiff end and faster cell migration emerged on the substrates with stronger gradient strengths.

Guidance of smooth muscle cell migration on photocrosslinked polymer substrates with stiffness gradient

249th National Meeting (2015)

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