<i>Escherichia coli</i> enzyme AlkB as well as its human homologs ALKBH1 through ALKBH8 and FTO have an important function of removing alkyl groups from DNA bases. These enzymes have high sequence similarity. ALKBH1 is of particular interest because of its substrate specificity and the fact that it also has a lyase activity, which other ALKBH enzymes do not have. In this contribution we will present results for a homology model, molecular dynamics simulations, and mutagenesis studies of ALKBH1. Structural and functional impact of important residues obtained from these results will be discussed.

Homology modeling and molecular dynamics study of ALKBH1 enzyme

249th National Meeting (2015)

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