Molecularly imprinted polymers (MIPs) are useful in many fields due to their molecular recognition. These uses include separations, sensors, assays, and catalysis. The imprinting is accomplished by polymerizing a monomer with a template molecule. The template can be removed leaving behind a specific binding cavity for that same template. A large focus has been on the crosslinker N,α-bismethacryloyl alanine (NALA) for its chiral selectivity as an OMNiMIP (one monomer molecularly imprinted polymer). NALA was imprinted with L and/or D-Boc Tyrosine to test its binding capabilities with these enantiomers. All of the polymers are tested by high performance liquid chromatography (HPLC) and/or batch rebinding. Batch rebinding and chromatographic techniques allow for the analysis of both thermodynamic and kinetic binding measurements respectively. Different variations of imprints along with different size ranges of the imprinted polymers were evaluated. The information gathered from this MIP was useful to understand NALA’s diastereomeric or enantiomeric effects upon separating enantiomers.

Exploring a chiral cross-linker by molecular imprinting using chromatographic and batch rebinding techniques

249th National Meeting (2015)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.