We have developed a set of new transition metal-catalyzed methodologies for synthesis of furan, pyrrole, and N-fused heterocycles.  These methods operate via several types of novel cycloisomerizations, including migratory cycloisomerizations, and recently discovered transannulation reaction.<br/> <br/>We have also developed several new two- and tri-component coupling reactions toward synthesis of indolizines, indolines, indoles, and imidazopyridines.  Some of these methods have been applied to a synthesis of focused and mid-sized libraries of small molecules for wide biological screening.<br/> <br/>The scope of these and some other transformations will be demostrated and the mechanisms will be discussed.

Development of novel transition metal-catalyzed approaches toward heterocycles

249th National Meeting (2015)

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