A new and effective antibacterial wound dressing nanofibers based on chitosan iodo-acetamide was successfully prepared via electrospinning. Chitosan derivative, chitosan iodo-acetamide, was obtained by the introduction of Iodoacetic acid moiety to the chains of chitosan polymer. The reaction was mediated through carbondiimide intermediate using ethyl-3(3-dimethylamminopropyl) carbondiimide hydrochloride (EDAC) as a coupling agent. The chemical structure was verified by FT-IR and <sup>1</sup>H NMR spectra. Chitosan iodo-acetamide derivative was found to react with th e cysteine residuals, of the outer cellular membrane of the bacteria, faster than its thiolated counterparts. Electrospun nanofiber mats were obtained from PVA/CS, PVA/CS/thiol chitosan, and PVA/CS/chitosan Iodoacetamide blended solutions. PVA/CS/chitosan Iodoacetamide blended solutions showed superior morphological and antibacterial properties over that obtained from PVA/CS/thiol-chitosan. The antimicrobial activity of the nanofiber mats were performed against gram negative bacteria <i>E. coli. </i>PVA/CS/chitosan Iodoacetamide showed bactericidal activity after only 4h of treatment, whereas, PVA/CS/thiol-chitosan after 24h.

Antibacterial wound dressing electrospun nanofibers from chitosan - iodoacetamide

249th National Meeting (2015)

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