The microwave-accelerated reaction of alkynones with para-sulfonamidophenylhydrazine provides an effective method for the synthesis of a diverse group of trisubstituted pyrazoles. This reaction is a domino combination of a condensation and a 5-exo-dig cyclization that proceeds in the absence of solvent using montmorillonite K-10, which acts as a catalyst and a reaction medium. This method allows for the introduction of a para-sulfonamidophenyl substituent at the N-1 of the pyrazole, which is an effectively applied motif in related pharmaceutically-active compounds.

Synthesis of pyrazol-1-yl-benzenesulfonamides

249th National Meeting (2015)

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