In recent years, numerous concerns have been raised on endocrine disrupting chemicals (EDCs) due to their widespread occurrence in aquatic environments. It has been claimed that EDCs might interact directly with one or more components of the endocrine system, thereby causing malfunctions and, ultimately, health problems to organisms. Ozone, a strong oxidant, has been used to treat organic pollutants including EDCs for the past few decades. However, ozonation treatment is incapable of removing all the EDCs and degradates although it’s more effective than other advanced oxidation process. Therefore, the present study aims to evaluate the performance of ozonation and reveal the biological risk of EDCs and degradates by combination of mass measurement and bioassay monitoring. Triclosan, N,N-Diethyl-3-methylbenzamide (DEET) and chlorpropham are chosen as the targeted EDCs for this study. Mass measurement techniques based on UPLC-UV, HPLC-MS, GC-MS and TOC are used to identify and quantify the EDCs and degradates. Afterwards, bioassays such as Yeast Estrogenic Screen (YES), SOS/umu genotoxicity assay and microtox assays are employed to monitor the biological potency including (anti-) estrogenic effect, genotoxicity and acute toxicity, of EDCs and mixture of degradates during ozonation treatment. An attempt to link major degradates with the measured biological potency will contribute to uncovering the correlation (e.g., synergetic and antagonistic effect) among the pollutants and their degradates.

Biological risk assessment of EDCs degradation by ozone

249th National Meeting (2015)

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