Polyurea glycopolymers were synthesized from acetyl protected either mannose- or lactose-containing diamines with four different diisocyanates, namely toluene 2,4-diisocyanate (TDI), isophorone diisocyanate (IPDI), 4,4'-methylenebis(cyclohexyl isocyanate (HMDI) and hexamethylene diisocyanate (HDI), via step-growth polymerization. The obtained acetyl protected glycopolymers were further deprotected and sulfated to obtain sulfated glycopolymers. The influence of the diisocyanates comonomers in terms of the polymers anticoagulant properties was investigated by measuring the activated partial thromboplastin time of the sulfated glycopolymers. The results indicated that IPDI and HMDI-containing sulfated glycopolymers exhibited higher prolongation of the activated partial thromboplastin time than the corresponding TDI and HDI-containing glycopolymers.

Polyurea glycopolymers from lactose and mannose modified-diamines with different diisocyanate comonomers: Synthesis and anticoagulant properties

249th National Meeting (2015)

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