Copper, cobalt and nickel organometallic complexes continue to be of interest to our research group as these compounds may find use as anti-cancer, anti-fungal or anti-bacterial compounds.  Hydrozones have shown biological activity as anti-tumor, anti-viral and anti-mycobacterial agents along with other applications.  One recent water-soluble hydrazone thiophene ligand synthesized by Morales-Toyo, et.al. (J. Chem. Cryst, 2013, 43, 544-549) may offer an opportunity to increase the water solubility of select metal compounds, thereby making them potentially more biologically active.  The reaction of copper and cobalt with these hydrozone thiophene ligands may result in compounds of biological significance along with improved water solubility.  A new ligand, (E)-Ethyl-2-[2-(thiophen-2-ylmethylene) hydrazinyl] benzoate has been synthesized and characterized by NMR and IR.  Additionally, preliminary results of bacterial testing with this ligand are shown.

Synthesis and characterization of a novel hydrozone thiophene ligand

249th National Meeting (2015)

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