The anti-tumor effects of imidazolium salts on non-small cell lung carcinoma cell lines have been previously determined by MTT assay, showing their great potential as future chemotherapeutic agents. By varying the substituents on the imidazole, a variety of activity levels have been seen, most notably numerous IC<sub>50</sub> values are in the single digit µM range. Planar substituents on the nitrogen atoms have given rise to compounds with great potential. Due to their planar nature, it is proposed that these compounds may interact with DNA. The variability in IC<sub>50</sub> values of these compounds show that not all imidazolium salts behave in the same way. Annexin V staining and fluorescent intercalator displacement assays are employed to identify apoptosis and determine the level of interaction with DNA.

Mechanistic studies of imidazolium salts as antitumor agents

249th National Meeting (2015)

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