Tailored biomolecular materials gain rising attention as bio-sensors, artificial enzymes, light harvesting systems, photonics and nanoelectronic devices. Thus, the formation of higher order molecularly organized structures is widely explored, in particular to gain more control over shape, size and function. In this work artificial supramolecular structures of dendronized glycopolymers are investigated. The self-aggregation properties of these worm-like polymers were found to be dependent on pH value, molar mass and concentration. The shape of the aggregates is changing strongly as a result of changing H-bonding interactions. Additionally to dendronized polymers, block-copolymers self-organization in polymersome structures was studied for the complexation and transport of enzymes. Their shape and activity dependence on the pH value is significant. Complementary application of filed flow fractionation coupled to several detectors and AFM, cryo-TEM or TEM tomography show the high potential of combined separation techniques for scaling and interaction properties investigation of biomolecular systems.

Self-organization phenomena in biomacromolecules investigated by field flow fractionation

249th National Meeting (2015)

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