The development of new nitroxyl (HNO) donors has received increasing attention due to their promise for treating congestive heart failure. We are developing new HNO donors, suitable for studying the fundamental bioinorganic chemistry of HNO, which rapidly release HNO via photoactivation. Herein, we report the synthesis of a new family of photoactivatable HNO donors 1 based on the use of the (3-hydroxy-2-naphthalenyl)methyl (HNM) phototrigger. Mechanistic photochemical studies of 1 leading to HNO generation (along with a competing side reaction) are discussed.

Synthesis and photolysis of a novel family of photoactivatable HNO donors using the (3-hydroxy-2-naphthalenyl)methyl photolabile protecting group

249th National Meeting (2015)

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