Superoxide dismutases (SODs) are a family of enzymes that catalyze the dismutation of superoxide radical anions (O2-) to hydrogen peroxide and molecular oxygen, thereby protecting cells from this damaging reactive oxygen species. However, an excess of O2- can be produced by the immune system in response to inflammatory diseases or strokes, overwhelming locally available SOD. Low molecular weight compounds that mimic SOD activity are therefore of interest as potential pharmaceuticals. The goal of our work is to synthesize complexes that resemble the active site center of manganese(III) ion-containing SOD and to examine these complexes for their ability to dismutate superoxide ion. The synthesis and characterization of two such complexes from tetradentate ligands containing either pyridine or quinoline moieties is described herein. Characterization of these complexes has been achieved by FT-IR and UV-vis spectroscopy, and elemental analysis. Using the Fridovich assay, we have demonstrated that these complexes are active SOD mimics.

Synthesis and reactivity of manganese(III) complexes with tetradentate ligands that mimic superoxide dismutase enzymes

249th National Meeting (2015)

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Synthesis and reactivity of manganese(III) complexes with tetradentate ligands that mimic superoxide dismutase enzymes<br />