We present a degradable hydrogel system for drug delivery using oxime click chemistry by employing a ketone-functionalized polyester and an amino-oxy functionalized polyglycidol. The biocompatibility and orthogonal nature of this chemistry makes these gels an attractive option for the delivery of both synthetic and biological therapeutics. Additionally, the synthesis method for these materials allows for control over the properties of the resulting gel based upon the ratio between the polyester precursor and the polyglycidol crosslinker. The potential of these gels to serve as a successful delivery platform was assessed by studying the swelling and degradation profiles, as well as the in vitro release rate of a model drug. Biocompatibility and cytotoxicity of the gels were studied using NIH 3T3 cells. Because of the orthogonal nature of this crosslinking chemistry, these gels also have the potential to be utilized as a platform for a more complex delivery system, and could be used to encapsulate an additional delivery vehicle. Polyester nanosponges formed using amine-epoxide chemistry have been successfully synthesized in our lab and have been shown to be an effective delivery vehicle for a number of hydrophobic drugs, both in vitro and in vivo. These particles can be entrapped within the gel matrix and serve as an ancillary boundary to the release of a therapeutic, which lends an additional degree of tailoring to the release rate.

Synthesis of a biocompatible hydrogel platform for drug delivery using oxime click chemistry

249th National Meeting (2015)

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