Molecularly imprinted polymers (MIPs) are synthesized from one or more functional organic monomers that self-assemble around a target template (e.g. small organic molecules or large biological molecules). Following polymerization and removal of the template, these MIPs can be used to detect free template. One of the most attractive features of MIPs as the capture component of biosensors is the increased lifetime and the reusability of the sensors. Here we present the construction of novel electrochemical sensors for peptides using a bifunctional monomer (N-phenylethylene diamine methacrylamide), in combination with other functional monomers specially designed based on interactions with the templates, and cross-linkers formed by electropolymerization and photochemical polymerization. The sensitivity and selectivity of the resulting sensors were further investigated. These MIP based sensors have the potential to be a useful technique for the electrochemical determination of peptides.

Molecularly imprinted polymer-based electrochemical sensor for peptides

249th National Meeting (2015)

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