Naturally occurring antimicrobial peptides (AMPs) are amphipathic molecules that eliminate a wide range of bacteria and are found in a variety of eukaryotic organisms. Unlike current synthetic antibiotics, bacteria do not appear to develop resistance to AMPs, and these peptides are highly selective. Synthetic mimics of AMPs are of interest for their potential cost effectiveness and ability to target specific bacteria. Statistical copolymers of aminopropyl methacrylamide (APMA) (lysine mimic) and guanadinopropyl methacrylamide (GPMA) (arginine mimic) were synthesized via aqueous RAFT polymerization. Antimicrobial activity against E. coli, S. aureus, and P. aeruginosa was evaluated. Specific compositions provided high activity and selectivity. Attempts to determine mechanism of activity will be described.

Broad spectrum antimicrobial effectiveness for synthetic mimic of antimicrobial peptides

249th National Meeting (2015)

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